INDUCTION OF ANGIOGENESIS BY A TYPE III PHOSPHODIESTERASE INHIBITOR THROUGH ACTIVATION OF PPAR GAMMA AND cAMP PATHWAYS
نویسندگان
چکیده
Objective: Peripheral arterial disease (PAD) is highly prevalent in the elderly as well as in the subjects with cardiovascular risk factors such as diabetes. Approximately 2–4% of those affected with PAD commonly complain of intermittent claudication (IC). Cilostazol, a type III phosphodiesterase inhibitor, is the only FDA-approved drug for the treatment of IC. Cilostazol has been shown to be benefi cial for the improvement of pain-free walking distance in patients with IC in a series of randomized clinical trials. However, the underlying mechanism how cilostazol improved IC symptoms is still unclear.
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